水分蒸散量測定装置(TEWL計)：　ﾎﾟｰﾀﾌﾞﾙ水分蒸散計　VapoMeter® ﾊﾞﾎﾟﾒｰﾀｰ

本体の開口部から内蔵センサーまでの構造は、ほぼ密閉された円筒の形をしています。測定は本体のスイッチを押し、電子音の合図で測定部位に開口部を押し当てると約７－12秒間で測定が行われます。内部のセンサーがこの間のＴＥＷＬ値を計算し、外気の湿度と相対温度も合わせて表示します。換気時間の調整中はスタートボタンにロックがかかり、換気終了と同時に再度スタートが可能になります。

従来型経皮蒸散量測定機器との比較

上のグラフは古くから使用されている開放型蒸散計との比較です。機器が理論上の計算でどれだけ正確かを実験するためメンブレン（水蒸気を通す膜）で覆われた皮膚モデルからの蒸散を測定します。ＶａｐｏＭｅｔｅｒでの蒸散量測定値と計算上の蒸散値では220ｇ/ｍ2ｈまで高い相関がれあられました。一方の開放型蒸散計では120ｇ/ｍ2付近から著しい相違が見られます。

・植物・物体・素材からの水分蒸発量の測定
・バリア機能の観察・評価
・刺激性試験での指標
・フランツセルでの３D膜等の確認

本体

データ記録用ソフト　DelfWin

TEWL、皮膚バリア機能、透過試験

Increased permeability for polyethylene glycols through skin compromised by sodium lauryl sulphate
Jakasa I., Verberk M.M., Bunge A.L., Kruse J. and Kezic S.
Exp Dermatol, Oct;15(10): 801-7, 2006.

Altered penetration of polyethylene glycols into uninvolved skin of atopic dermatitis patienst
Jakasa I., Verberk M.M., Esposito M., Bos J.D. and Kezic S.
J Invest Dermatol, 127: 129-134, 2006.

'Keratolytic' properties of benzoyl peroxide and retinoic acid resemble salicylic acid in man
Waller J.M., Dreher F., Benham S., Ford C., Lee C., Tiet T., Weinstein G.D. and Maibach H.I.
Skin Pharmacol Physiol, Vol 19(5): 283-289, 2006.

Percutaneous penetration of sodium lauryl sulphate is increased in uninvolved skin of patients with atopic dermatitis compared with control subjects
Jakasa I., de Jongh C.M., Verberk M.M., Bos J.D. and Kezic S.
Br J Dermatol, Jul;155(1): 104-9 2006.

Variation in barrier impairment and inflammation of human skin as determined by sodium lauryl sulphate penetration rate
De Jongh C.M., Jakasa I., Verberk M.M. and Kezic S.
Br J Dermatol, Apr;154(4): 651-7, 2006.

Transepidermal water loss reflects permeability barrier status: validation in human and rodent in vivo and ex vivo models
Fluhr J.W., Feingold K.R. and Elias P.M.
Exp Dermatol, Jul;15(7): 483-92, 2006.

Retroperitoneoscopic lumbar sympathectomy for the treatment of plantar hyperhidrosis: technique and preliminary findings
Rieger R. and Pedevilla S.
Surg Endosc, Jan;21(1):129-35, 2007

Abstracts

Comparison of two instruments to assess scalp barrier function
Bacon R., Billhimer, W., Ertel, K. and Watson, D.
Skin Res Technol, Vol 10: 13, 2004.

Assessment of permeability barrier function measuring transepidermal water loss: comparing 3 closed-loop systems and 4 open-loop systems in vivo and in vitro
Fluhr, J. W., Bankova, L., Elias, P. M. and Feingold, K. R.
Skin Res Technol, Vol 9 (2): 164, 2003.

荒れ

A randomized, controlled, double-blind study of the effect of wearing coated pH 5.5 latex gloves compared with standard powder-free latex gloves on skin pH, transepidermal water loss and skin irritation.
Mirza R., Maani N., Liu C., Kim J. and Rehmus W.
Contact Dermatitis, Jul;55(1): 20-5, 2006.

Stratum corneum cytokines and skin irritation response to sodium lauryl sulfate
de Jongh C.M., Verberk M.M., Withagen C.E.T., Jacobs J.J.L., Rustemeyer T. and Kezic S.
Contact Dermatitis, Jun;54(6):325-33, 2006.

Skin reaction and recovery: a repeated sodium lauryl sulphate patch test vs. a 24-h patch test and tape stripping
Koopman D.G., Kezic S., Verberk M.M.
Br J Dermatol, Mar;150(3):493-9, 2004.

スキンケア、スキントリートメント、栄養効果

Evaluation of the antioxidant capacity and preventive effects of a topical emulsion and its vehicle control on the skin response to UV exposure
Zhai H., Behnam S., Villarama C.D., Arens-Corell M., Choi M.J. and Maibach H.I.
Skin Pharmacol Physiol, 18: 288-293, 2005.

Efficacy of dietary hempseed oil in patients with atopic dermatitis
Callaway J., Schwab U., Harvima I., Halonen P., Mykkanen O., Hyvonen P. and Jarvinen T.
Dermatology Treat, 16: 87-94, 2005.

Moisturizing effects of topical nicotinamide on atopic dry skin
Soma Y., Kashima M., Imaizumi A., Takahama H., Kawakami T. and Mizoguchi M.
Int J Dermatol, Mar;44(3): 197-202, 2005

Abstracts

Susceptibility to SLS irritation: Effect of a five-day pre-use of two skin care oils studied comparing various techniques and instruments
Rantanen, T., Snellman, E. and Kostiainen M.
First World Congress on Work-Related and Environmental Allergy, 9-12 July 2003: p. 95.

幼児のSSWL、おむつ

Abstracts

Measurement of skin hydration in the diapered area of infants with a closed chamber TEWL meter
Alanen, E., Wiesemann, F., Nuutinen, J. and Lahtinen, T.
Skin Res Technol, Vol 9 (2): 199, 2003.

動物皮膚、トリートメント、栄養効果

Cutaneous water loss and lipids of the stratum corneum in dusky anticirds, a lowland tropical bird
Munos-Garcia A. and Williams J.B.
The Condor, 109:59-66, 2007.

Abstracts

Regional differences in sweat rate response of steers to short-term heat stress
Spiers D.E., Wax L.E., Scharf B. and Aiken G.E.
J Anim Sci, Vol 84, Suppl 1/J Dairy Sci, Vol 89, Suppl 1: 303-304, 2006.

Effects of ambient temperature and solar radiation on skin evaporative water loss in dairy cattle
Pollar B.C., Dwyer, M.E., Fitzgerald A.C., Gentry P.C., Henderson D.A. and Collier R.J.
J Anim Sci, Vol 82, Suppl 1/J Dairy Sci, Vol 87, Suppl 1/Poult Sci Vol 83, Suppl 1: 198, 2006.

Impact of alcohol consumption on the skin as determined by non-invasive bioengineering tools
Brand R.M., Jendrzejewski J.L. and Charron A.R.
Society of Toxicology Meeting, March 2006.

Effects of ambient temperature and solar radiation on skin evaporative water loss in dairy cattle
Pollard, B. C., Dwyer, M. E., Fitzgerald, A. C., Gentry, P. C., Henderson, D. A. and Collier, R. J.
J Anim Sci, Vol 82, Suppl. 1/ J Dairy Sci, Vol 87, Suppl. 1/ Poult Sci, Vol 83, Suppl. 1. 198, 2004.

Heat dissipation in winter-acclimated lactating cows and non-lactating heifers subjected to increased ambient temperature and solar radiation in Arizona
Pollard, B. C., Annen, E. A., Baumgard, L. H., Cheatham, R. C., Estheimer, M. D., Dwyer, M. E., Fitzgerald, A. C., Halfliger, H. C., Moore, C. E., Kay, J. K., Mendivil, O. B., Gentry, P. C., Henderson, D. A., Steining, C. M. and Collier, R. J.
J Anim Sci, Vol 82, Suppl. 1/ J Dairy Sci, Vol 87, Suppl. 1/ Poult Sci, Vol 83, Suppl. 1. 461, 2004.

In-vitro試験

Vitamin C enhances differentation of a continuous keratinocyte cell line (REK) into epidermis with normal stratum cornuem ultrasructure and functional permeability barrier
Pasonen-Seppanen S., Suhonen T.M.,Kirjavainen M., Suihko E.,Urtti A., Miettinen M., Hyttinen M., Tammi M. and Tammi R.
Histocem Cell Biol, 116: 287-297, 2001.

Formation of permeability barrier in epidermal organotypic culture for studies on drug transport
Pasonen-Seppanen S., Suhonen T.M.,Kirjavainen M., Miettinen M., Urtti A., Tammi M. and Tammi R.
J Invest Dermatol, Vol 117, No 5, 1322-1324, November 2001.

バリデーション

Tape-stripping method in man: comparison of evaporimetric methods
Zhai H., Dika E., Goldovsky M. and Maibach H.I.
Skin Res Technol, Vol 13: 207-210, 2007.

Measurement of transepidermal water loss by closed-chamber systems
Nuutinen J.
in Serup J., Jemec G.B.E. and Grove G., (eds.), Handbook of non-invasive methods and the skin, 2nd edition, CRC Press, Boca Raton, FL, pp. 393-396, 2006.

Comparative evaporimetry in man
Shah J.H., Zhai H. and Maibach H.I.
Skin Res Technol, Vol 11: 205-208, 2005.

Validation of the VapoMeter, a closed unventilated chamber system to assess transepidermal water loss vs. the open chamber Tewameter
De Paepe K., Houben E., Adam R., Wieswmann F. and Rogiers V.
Skin Res Technol, Vol 11: 61-69, 2005.

Water loss through lip, nail, eyelid skin, scalp skin and axillar skin measured with a closed-chamber evaporation principle
Nuutinen J., Harvima I., Lahtinen M.-R. and Lahtinen T.
Br J Dermatol, 148: 839-841, 2003.

A closed unventilated chamber for the measurement of transepidermal water loss
Nuutinen J., Alanen E., Autio P., Lahtinen M-R., Harvima I. and Lahtinen T.
Skin Res Technol, Vol 9: 85-89, 2003.

Abstracts

Applicability of the closed unventilated VapoMeter to assess transepidermal water loss (TEWL) on nasolabial skin areas
De Paepe, K., Houben, E., Adam, R., Wiesemann, F. and Rogiers, V.
Skin Res Technol, Vol 10: 3, 2004.

Comparison of two methods for TEWL measurement
Shah J.H., Zhai H., Maibach H.I. and Nuutinen J.
Skin Res Technol, Vol 10, 2004.

Measurement of water evaporation rates with a closed chamber TEWL meter
Nuutinen, J., Alanen, E. and Lahtinen, T.
Skin Res Technol, Vol 9 (2): 183, 2003.